ea0070aep146 | Bone and Calcium | ECE2020
Kushchayeva Yevgeniya
, Abdullah Idri
, Kushchayev Sergiy
, Auh Sungyoung
, Startzell Megan
, Cochran Elaine
, Brown Rebecca
Introduction: Diabetes is associated with increased fracture risk both in patients with type 1 (T1D) and type 2 diabetes (T2D) despite differences in bone mineral density BMD (decreased in T1D and increased in T2D). In T2D, insulin resistance (IR) is selective, with some insulin signaling pathways impaired, while others are overactive due to hyperinsulinemia. It is not clear how different insulin signaling pathways might contribute to the bone phenotypes observed in diabetes. ...